Patent · US Expired

Sustained release formulations containing acetaminophen and tramadol

US7374781B2 · kind B2 · utility

25Cited by
3References
9Claims
0Family size

Inventors

Key dates

Filing dateSep 20, 2003
Grant dateMay 20, 2008
Priority date—
Expiry dateAug 19, 2025

Classification

  • Technology area (CPC A)Human Necessities
  • CPC primaryA61K9/5084
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

A sustained release formulation as a unit dose contains 100 mg-1000 mg of Acetaminophen and 15 mg-150 mg of tramadol hydrochloride, which comprises of 1) an immediate release portion comprising of 25%-75% of the total effective amount of drug in the dosage form and 2) a sustained release portion comprising of a) 25%-75% of the total effective amount of drugs in the dosage form; b) 6%-50% of gelling polymers of the total formulation, and c) optionally an enteric coating at a level of 5%-40% of the total formulation. The set forth formulation dissolves 25%-60% of the total drug in the first hour, 50%-90% of the total drug in the first four hours and not less than 80% of the total drug in the first 12 hours using USP dissolution method II at 50 rpm.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.