Methods for identifying compounds that modulate ΔTRα2 activity
US7374890B2 · kind B2 · utility
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1References
21Claims
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Key dates
| Filing date | Apr 12, 2004 |
| Grant date | May 20, 2008 |
| Priority date | — |
| Expiry date | Jun 27, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Truncated thyroid hormone receptors ΔTRα1 and ΔTRα2 have been discovered to play a role in actin-based endocytosis, e.g., in the nervous system. The invention relates to methods of discovering ligands effective in modulating endocytosis and transgenic mice with altered expression of ΔTRα1 and ΔTRα2. The invention is useful for the discovery and testing of compounds for treating disorders of the nervous system such as depression.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.