Bis-indole pyrroles useful as antimicrobials agents

US7375129B2 · kind B2 · utility

Assignee

• Nereus Pharmaceuticals, Inc. · US

Inventors

• Scott S. Mitchell · Redwood City, US
• Kin S. Lam · Cheshire, US
• Jennifer Grodberg · Montréal, CA
• Barbara Potts · Escondido, US
• Ginger Tsueng · San Diego, US
• Donald James White, Jr. · Lancaster, US
• Katherine Reed · San Diego, US

Key dates

• Filing date: Nov 20, 2006
• Grant date: May 20, 2008
• Expiry date: Nov 20, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D403/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.