Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a thioredoxin-like 32 kDa protein
US7378251B2 · kind B2 · utility
1Cited by
3References
28Claims
0Family size
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Key dates
| Filing date | Jul 16, 2002 |
| Grant date | May 27, 2008 |
| Priority date | — |
| Expiry date | Jul 16, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a thioredoxin-like 32 kDa protein (TXNL) as a surrogate analyte and methods of using the compounds in a variety of in vitro, in vitro and ex vivo contexts.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.