NF-kappaB oligonucleotide decoy molecules

US7378509B2 · kind B2 · utility

Assignee

• ANESIVA, INC. · US

Inventors

• Leslie McEvoy · Mountain View, US
• Christi L. Parham · Menlo Park, US
• Jie Zhang · Beijing, CN
• Rolf Ehrhardt · Mill Valley, US

Key dates

• Filing date: Dec 2, 2004
• Grant date: May 27, 2008
• Expiry date: Dec 2, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2310/53
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention concerns double-stranded NF-κB decoy oligodeoxynucleotide (NF-κB dsODN) molecules that contain a core sequence capable of specific binding to an NF-κB transcription factor. In a particular aspect, the invention concerns NF-κB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-κB decoy molecules with improved binding affinity to p65.