Adduct of topiramate and tramadol hydrochloride and uses thereof

US7378519B2 · kind B2 · utility

Assignee

• Cilag GmbH International · CH

Inventors

• Rainer Naeff · Langwiesen, CH
• Sonja Spycher-Huber · Benken, CH
• Thomas Hunziker · Thun, CH
• Guenter Laufer · Singen, DE

Key dates

• Filing date: May 16, 2003
• Grant date: May 27, 2008
• Expiry date: May 16, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Processes for isolation and purification of enantiomerically enriched compositions comprising tramadol and topiramate, and also for the subsequent isolation of 1S,2S-tramadol hydrochloride, are disclosed herein.