Stable pharmaceutical solution formulations for pressurized metered dose inhalers

US7381402B2 · kind B2 · utility

Assignee

• Chiesi Farmaceutici S.p.A. · IT

Inventors

• David Lewis · Carmel, US
• David Ganderton · Exeter, GB
• Brian Meakin · Bath, GB
• Maurizio Delcanale · Parma, IT
• Fausto Pivetti · Parma, IT

Key dates

• Filing date: Feb 25, 2005
• Grant date: Jun 3, 2008
• Expiry date: Feb 25, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61M2205/0222
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Aerosol solution formulations for use in an aerosol inhaler which comprise 8-hydroxy-5-[(1R)-1-hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]-ethyl]-2(1H)-quinolinone or a salt thereof, in particular the hydrochloride salt (TA 2005), as an active ingredient, a propellant containing a hydrofluoroalkane, and a cosolvent, stabilized by addition of a specific small amount of a high concentrated phosphoric acid exhibit improved shelf life. The formulation may be optionally contained in a can having part or all of its internal metallic surfaces lined with an inert organic coating.