Antibodies specific for sclerostin and methods of screening and use therefor
US7381409B2 · kind B2 · utility
53Cited by
10References
16Claims
0Family size
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Key dates
| Filing date | Jun 15, 2004 |
| Grant date | Jun 3, 2008 |
| Priority date | — |
| Expiry date | Jul 1, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/4704
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Compositions and methods relating to antibodies that specifically bind to TGF-beta binding proteins are provided. These methods and compositions relate to altering bone mineral density by interfering with the interaction between a TGF-beta binding protein sclerostin and a TGF-beta superfamily member, particularly a bone morphogenic protein. Increasing bone mineral density has uses in diseases and conditions in which low bone mineral density typifies the condition, such as osteopenia, osteoporosis, and bone fractures.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.