Non-endogenous, constitutively activated known G protein-coupled receptors
US7381522B2 · kind B2 · utility
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3Claims
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Key dates
| Filing date | Apr 14, 2006 |
| Grant date | Jun 3, 2008 |
| Priority date | — |
| Expiry date | Apr 14, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is known (“known GPCRs”), and most particularly to mutated (non-endogenous) versions of the known GPCRs for use, most preferably in screening assays for the direct identification of candidate compounds as inverse agonists, agonists and partial agonists.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.