Methods for identifying compounds for treating diabetes mellitus
US7381523B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 25, 2006 |
| Grant date | Jun 3, 2008 |
| Priority date | — |
| Expiry date | Aug 25, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/042
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention is directed to methods for identifying candidate beta cell-sensitizing compounds comprising providing a pancreatic beta islet cell population derived from a diabetic subject, contacting the beta islet cell population with one or more somatostatin receptor 5-binding compounds, and identifying those somatostatin receptor 5-binding compounds that promote insulin secretion from the pancreatic beta islet cell population at a higher rate than from a control cell population. The invention is further directed to methods for treating type II diabetes comprising administering a beta cell-sensitizing compound identified by the first method of the invention to a diabetic patient in need of treatment.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.