Nucleic acids encoding estrogen receptor ligand binding domain variants

US7381813B2 · kind B2 · utility

Assignee

• Novartis AG · CH

Inventors

• Kathryn Rene Bracken · Swampscott, US
• Joseph de los Angeles · Cranford, US
• Ying Huang · Shandong, CN
• Michael Joseph Kadan · Hampstead, US
• Gary Michael Ksander · Carmel, US
• Dennis Bryan Zerby · Myersville, US

Key dates

• Filing date: May 31, 2002
• Grant date: Jun 3, 2008
• Expiry date: Aug 28, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Mutants of steroid receptor ligand binding domains and synthetic ligands which have specific binding affinities for these receptors are provided. The use of these LBD-ligand combinations for construction of selective “molecular gene switches” is disclosed. Methods of regulating gene function using these switches are provided.