Process for preparing cyclohexanediacetic acid monoamide
US7381823B2 · kind B2 · utility
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Key dates
| Filing date | Mar 17, 2005 |
| Grant date | Jun 3, 2008 |
| Priority date | — |
| Expiry date | Jun 18, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D221/20
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.