Methods of treating or preventing an infectious disease using an immunogenic conjugate of a gram-negative bacterial autoinducer molecule

US7384639B2 · kind B2 · utility

Assignee

• University of Rochester · US

Inventors

• Andrew S. Kende · Pittsford, US
• Barbara H. Iglewski · Fairport, US
• Roger Smith · Madison, US
• Richard P. Phipps · Pittsford, US
• James Pearson · Cambridge, US

Key dates

• Filing date: Sep 6, 2005
• Grant date: Jun 10, 2008
• Expiry date: Sep 20, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S530/808
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.