Methods for predicting drug sensitivity in patients afflicted with an inflammatory disease
US7384736B2 · kind B2 · utility
6Cited by
1References
16Claims
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Key dates
| Filing date | Sep 6, 2001 |
| Grant date | Jun 10, 2008 |
| Priority date | — |
| Expiry date | Sep 6, 2021 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are disclosed for predicting the efficacy of a drug for treating an inflammatory disease in a human patient, including: obtaining a sample of cells from the patient; obtaining a gene expression profile of the sample in the absence and presence of in vitro modulation of the cells with specific cytokines and/or mediators; and comparing the gene expression profile of the sample with a reference gene expression profile, wherein similarities between the sample expression profile and the reference expression profile predicts the efficacy of the drug for treating the inflammatory disease in the patient.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.