DNA encoding a human imidazoline receptor and ligand binding assay employing same
US7384752B2 · kind B2 · utility
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Key dates
| Filing date | Apr 24, 2003 |
| Grant date | Jun 10, 2008 |
| Priority date | — |
| Expiry date | Aug 16, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A cDNA encoding a human imidazoline receptor is described. The amino acid sequence of the entire imidazoline receptor protein is identified, as well as a C-terminal fragment believed to contain the imidazoline binding site of the receptor. The protein is highly unique in its sequence and may represent the first in a novel family of receptor proteins. Methods of cloning the cDNA and expressing the imidazoline receptor in a host cell are described. Also, a screening method for identifying drugs that interact with the imidazoline receptor is described.
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