Hepatitis C Virus NS5B polymerase inhibitor binding pocket
US7386398B2 · kind B2 · utility
14Cited by
1References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 7, 2004 |
| Grant date | Jun 10, 2008 |
| Priority date | — |
| Expiry date | Oct 11, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2770/24222
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The HCV NS5B polymerase, when complexed with certain inhibitors, adopts a conformation in which the finger loop region defined by amino acid residues 18 to 35 is displaced to expose a binding pocket defined generally by amino acid residues 392, 393, 395, 396, 399, 424, 425, 428, 429, 492, 493, 494, 495, 496, 500 and 503. This newly exposed binding pocket defines a novel target in the search of further chemical entities which are capable of binding to HCV NS5B and modulating, or preferably inhibiting, the polymerase activity of HCV NS5B.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.