Tetrameric antibody complexes for blocking non-specific labeling of antigens
US7387897B2 · kind B2 · utility
2Cited by
2References
6Claims
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Key dates
| Filing date | Sep 22, 2006 |
| Grant date | Jun 17, 2008 |
| Priority date | — |
| Expiry date | Dec 16, 2026 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/825
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method for preventing or inhibiting non-specific binding reactions between a detection reagent and an antigen in an immunological assay is described. The method involves using tetrameric antibody complexes that can bind to the antigen and are comprised of two monoclonal antibodies of a first animal species linked to two monoclonal antibodies of a second animal species that can bind the antibodies of the first animal species. Preferably, the antigen is an Fc Receptor and the method reduces the binding of a detection antibody with Fc receptors present on the surface of many cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.