Compositions and methods for producing vascular occlusion using a solid-phase platelet binding agent
US7387994B2 · kind B2 · utility
1Cited by
1References
51Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 17, 2005 |
| Grant date | Jun 17, 2008 |
| Priority date | — |
| Expiry date | Aug 21, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/418
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to methods and compositions for targeting and delivering solid-phase platelet-dependent vascular occlusion agents. In particular, particles or coils or stents coated with platelet binding agents are directed to target vasculature, such as the vasculature of solid tumor masses or AV-malformations or aneurysms or endoleaks; the solid-phase agent then binds and activates platelets, which in turn bind and activate other platelets. This process results in the rapid formation of a platelet-mediated thrombus about the solid-phase agent causing vessel occlusion.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.