Non-steroidal progesting

US7388006B2 · kind B2 · utility

Assignee

• Bayer Schering Pharma AG · DE

Inventors

• Norbert Schmees · Berlin, DE
• Manfred Lehmann · Berlin, DE
• Ulrike Fuhrmann · Berlin, DE
• Peter Muhn · Berlin, DE
• Christa Hegele-Hartung · Neheim, DE
• Michael Klotzbuecher · Berlin, DE

Key dates

• Filing date: Mar 11, 2003
• Grant date: Jun 17, 2008
• Expiry date: Oct 18, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D265/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to non-steroidal progestins of the general formula (I)wherein or a pharmaceutically acceptable derivative or analogue thereof. These progestins are suitable for selectively modulating progesterone receptor mediated effects in different target tissues, particularly in uterine tissue versus breast tissue. Therefore, the progestins of the present invention, optionally in combination with estrogens, may be used for contraception (in particular in estrogen-free oral contraceptives), hormone replacement therapy and the treatment of gynecological disorders. The present invention furthermore relates to methods for selectively modulating progesterone receptor mediated effects in different target tissues or organs.