Gamma-lactams as beta-secretase inhibitors

US7388007B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Lorin A. Thompson, III · Higganum, US
• Kenneth M. Boy · Durham, US
• Jianliang Shi · Furlong, US
• John E. Macor · Guilford, US

Key dates

• Filing date: Aug 18, 2005
• Grant date: Jun 17, 2008
• Expiry date: Jan 26, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K5/06139
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is provided a series of novel substituted gamma-lactams of Formula (I)or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R4, R5 and R6 as defined herein, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.