Amino acids with affinity for the α2δ-protein

US7388023B2 · kind B2 · utility

Assignee

• WARNER-LAMBERT COMPANY LLC · US

Inventors

• Peter Garth Blazecka · Windsor, CA
• Joseph Richard Bozelak · Munith, US
• Norman Lloyd Colbry · Gregory, US
• Timothy T. Curran · Iron River, US
• Annise Paige Goodman · Farmington Hills, US
• Kevin Henegar · Portage, US
• Garrett Hoge · Ann Arbor, US
• Paul D. Johnson · Kalamazoo, US
• Augustine Osuma · Ann Arbor, US
• Mark Plummer · Westbrook, US
• Jacob Bradley Schwarz · San Ramon, US
• Derek Vrieze · Ann Arbor, US
• Ji Zhang · Dongguan, CN

Key dates

• Filing date: Dec 7, 2006
• Grant date: Jun 17, 2008
• Expiry date: Dec 8, 2026

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/582
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed are methods of making the β-amino acids.