Structure-based approach to design of inhibitors of protein-processivity factor interactions
US7388070B1 · kind B1 · utility
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Key dates
| Filing date | May 12, 2000 |
| Grant date | Jun 17, 2008 |
| Priority date | — |
| Expiry date | May 12, 2020 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the structure-based identification and selection of inhibitors of processivity factor binding to protein is disclosed herein. Characterization of the protein/processivity factor interface is given. Methods for the structure-based inhibition of processivity factor binding to protein are also given. One embodiment includes a class of peptidomimetics that mimic helical portions of proteins. In addition, methods of treatment of various diseases are given, using the inhibitors of the invention.
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