MAGE peptides presented by HLA class II molecules

US7388072B2 · kind B2 · utility

Assignee

• LUDWIG INSTITUTE FOR CANCER RESEARCH LTD · GB

Inventors

• Yi Zhang · Edison, US
• Pascal Chaux · Brussels, BE
• Thierry Boon-Falleur · Brussels, BE
• Pierre van der Bruggen · Brussels, BE

Key dates

• Filing date: May 23, 2003
• Grant date: Jun 17, 2008
• Expiry date: Sep 9, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of MAGE genes.