Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy
US7390784B2 · kind B2 · utility
24Cited by
11References
8Claims
0Family size
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Key dates
| Filing date | Dec 13, 2004 |
| Grant date | Jun 24, 2008 |
| Priority date | — |
| Expiry date | Oct 7, 2025 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S530/812
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional molecule is administered to the host. The bifunctional molecule binds to the presenter protein to produce a binary complex that exhibits at least one of improved affinity, specificity or selectivity as compared to the corresponding free drug. The subject methods and compositions find use in a variety of therapeutic applications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.