Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
US7393652B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Mar 23, 2005 |
| Grant date | Jul 1, 2008 |
| Priority date | — |
| Expiry date | Mar 23, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/326
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides novel 1,4-benzothiazepine intermediates and derivatives, methods for synthesizing same, and methods for assaying same. The present invention also provides methods for using these novel compounds to limit or prevent a decrease in the level of RyR2-bound FKBP12.6 in a subject; to prevent exercise-induced sudden cardiac death in a subject; and to treat or prevent heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmia in a subject. The present invention further provides methods for identifying an agent that enhances binding of RyR2 and FKBP12.6, and agents identified by these methods. Additionally, the present invention provides methods for identifying agents for use in treating or preventing heart failure, atrial fibrillation, or exercise-induced cardiac arrhythmia, and in preventing exercise-induced sudden cardiac death. Also provided are agents identified by such methods.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.