Formulation based on heparin, glycosaminoglycan or heparinoid, use of the formulation and the formulation base

US7393840B2 · kind B2 · utility

Assignee

• BASF SE

Inventors

• Jörg Rosenberg · Ellerstadt, DE
• Jorg Breitenbach · Mannheim, DE
• Dieter Herr · Altrip, DE
• Volker Laux · Mainz, DE
• Robert Heger · Heidelberg, DE

Key dates

• Filing date: May 29, 2001
• Grant date: Jul 1, 2008
• Expiry date: Aug 12, 2022

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to formulations based on at least one heparin, glycosaminoglycan or heparinoid and on a formulation base with a lipid component and a polymer component. The use of this formulation as drug form for oral administration of at least one heparin, glycosaminoglycan or heparinoid, and also a process for producing the formulations by mixing the formulation components to form a plastic mixture and, where appropriate, to manufacture the formulations as drug form, advantageously using melt extrusion, are described. The lipid component advantageously has active ingredient-promoting properties, while the polymer component is soluble or swellable. At least parts of the lipid component are embedded in a polymer matrix, preferably in the form of a molecular dispersion. The formulations can form emulsions in water or aqueous liquids.