Sleep inducing compounds and methods relating thereto

US7393865B2 · kind B2 · utility

Assignee

• Neurocrine Biosciences, Inc. · US

Inventors

• Graham Beaton · San Diego, US
• Wilna Moree · San Diego, US
• Florence Jovic · Los Angeles, US
• Timothy Richard Coon · Carlsbad, US
• Jinghua Yu · San Marcos, US

Key dates

• Filing date: Jun 17, 2005
• Grant date: Jul 1, 2008
• Expiry date: Dec 23, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Compounds having the following structure (I):including stereoisomers, prodrugs, and pharmaceutically acceptable salts, esters and solvates thereof, wherein R1, R2, R3a, R3b, L1, L2 and n are as defined herein. Such compounds generally function as H1 receptor ligands, and thus have utility as sleep inducing agents. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.