Transgenic mouse model for neurodegenerative diseases
US7393994B2 · kind B2 · utility
9Cited by
2References
20Claims
0Family size
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Key dates
| Filing date | Aug 20, 2001 |
| Grant date | Jul 1, 2008 |
| Priority date | — |
| Expiry date | Aug 21, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/008
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Alzheimer's disease, Parkinson's disease and Lewy body disease are the most commonly found neurodegenerative disorders in the elderly. The invention is a transgenic mouse that contains two transgenes, human α-synuclein and human amyloid precursor protein, which are responsible for the formation of the neuritic plaques, Lewy bodies and neurodegeneration seen in the above mentioned diseases. The transgenic mouse is an accurate model for disease by both functional and pathological assays.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.