Corneal cells expressing active agents and methods of use thereof
US7396528B2 · kind B2 · utility
0Cited by
2References
21Claims
0Family size
Inventors
Key dates
| Filing date | Jan 30, 2006 |
| Grant date | Jul 8, 2008 |
| Priority date | — |
| Expiry date | Jan 30, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to methods of modifying cells of corneal tissue to express an active agent, to modified corneal tissue, to vectors utilised in such methods and to methods of xeno- and allo-transplantation utilising the modified corneal tissue. The method of modifying cells of corneal tissue to express an active agent involves exposing harvested corneal tissue to an effective concentration for transfection of an expression vector which comprises a nucleotide sequence encoding for the active agent for a period sufficient to allow infection, such that cells of the corneal tissue will express the active agent.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.