Apparatus and method for delivery of mitomycin through an eluting biocompatible implantable medical device
US7396538B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 26, 2003 |
| Grant date | Jul 8, 2008 |
| Priority date | — |
| Expiry date | Apr 21, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2250/0067
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention is an apparatus and a method for delivery of mitomycin through an eluting biocompatible implantable medical device. A biocompatible drug release matrix comprises a biocompatible drug release matrix and a drug incorporated into the biocompatible drug release matrix. The drug has antibiotic and anti-proliferative properties and is an analogue related to the quinone-containing alkylating agents of a mitomycin family. The drug is initially released from the biocompatible drug release matrix at a faster rate followed by a release at a slower rate. The drug release rate maintains tissue level concentrations of the drug for at least two weeks after implantation of the medical device. The present invention provides a coating for a vascular prosthesis that elutes the drug at a controlled rate to inhibit proliferation of smooth muscle cells causing restenosis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.