Method of producing FR901228
US7396665B2 · kind B2 · utility
30Cited by
3References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 22, 2001 |
| Grant date | Jul 8, 2008 |
| Priority date | — |
| Expiry date | Aug 22, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/101
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Depsipeptides and congeners thereof are disclosed having structure (I), wherein m, n, p, q, X, R1, R2 and R3 are as defined herein. These compounds, including FR901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant. Also provided are methods for inhibiting lymphocyte activation, proliferation, and/or suppression of IL-2 secretion
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.