Nitric oxide enhancing diuretic compounds, compositions and methods of use

US7396829B2 · kind B2 · utility

Assignee

• Nitromed, Inc. · US

Inventors

• David S. Garvey · Dover, US
• L. Gordon Letts · Dover, US
• Richard A. Earl · Wilmington, US
• Maiko Ezawa · Acton, US
• Xinqin Fang · Lexington, US
• Ricky D. Gaston · Malden, US
• Subhash P. Khanapure · Clinton, US
• Chia-En Lin · Burlington, US
• Ramani R. Ranatunge · Lexington, US
• Cheri A. Stevenson · Haverhill, US
• Shiow-Jyi Wey · Billerica, US

Key dates

• Filing date: Feb 24, 2006
• Grant date: Jul 8, 2008
• Expiry date: Feb 24, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention describes novel compositions and kits comprising at least one nitric oxide enhancing diuretic compound, or pharmaceutically acceptable salts thereof, and, optionally, at least one nitric oxide enhancing compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating conditions resulting from excessive water and/or electrolyte retention; (b) treating cardiovascular diseases; (c) treating renovascular diseases; (d) treating diabetes; (e) treating diseases resulting from oxidative stress; (f) treating endothelial dysfunctions; (g) treating diseases caused by endothelial dysfunctions; (h) treating cirrhosis; (j) treating pre-eclampsia; (k) treating osteoporosis; (l) treating nephropathy; (m) treating peripheral vascular diseases; (n) treating portal hypertension; (o) treating central nervous system disorders; (p) treating metabolic syndrome; (q) treating sexual dysfunctions; and (r) hyperlipidemia. The nitric oxide enhancing diuretic compounds comprise at least one nitric oxide enhancing group linked to the diuretic compound through one or more sites such as carbon, oxygen and/or nitrogen via a bond or moiety that cannot be hydrolyzed.