Patent · US Active

Metal complexes derivatized with folate for use in diagnostic and therapeutic applications

US7399460B2 · kind B2 · utility

29Cited by

20References

30Claims

0Family size

Assignee

Bracco International BV · NL

Inventors

Paul W. Wedeking · Cranbury, US
Ruth E. Wager · Rockville, US
Thangavel Arunachalam · Plainsboro, US
Kondareddiar Ramalingam
Karen E. Linder · Kingston, US
Ramachandran Ranganathan · Princeton, US
Adrian D. Nunn · Lambertville, US
Nataranjan Raju · Kendall Park, US
Michael F. Tweedle · Princeton, US

Key dates

Filing date	Sep 25, 2006
Grant date	Jul 15, 2008
Priority date	—
Expiry date	Nov 11, 2026

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P35/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Diagnostic and therapeutic compositions in the form of complexes for enhancing transmembrane transport of a diagnostic or therapeutic agent and methods for their use. The complexes contain the α, γ, or bis isomers of folate receptor-binding analogs of folate, a metal chelated by a ligand, and in one embodiment, a chemotherapeutic agent.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.