HSA-free formulations of interferon-beta
US7399463B2 · kind B2 · utility
10Cited by
18References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Apr 9, 2004 |
| Grant date | Jul 15, 2008 |
| Priority date | — |
| Expiry date | Jul 6, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Stabilized pharmaceutical compositions comprising substantially monomeric interferon-beta (IFN-β) and methods useful in their preparation are provided. The compositions comprise the IFN-β solubilized in a low-ionic-strength formulation that maintains the composition at a pH of about 3.0 to about 5.0. Methods for preparing these compositions, and for increasing solubility of IFN-β in pharmaceutical compositions, are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.