Method and compositions for promoting osteogenesis
US7399466B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 23, 2001 |
| Grant date | Jul 15, 2008 |
| Priority date | — |
| Expiry date | May 2, 2022 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/108
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The object of the present invention is to increase PHEX activity to improve the osteogenic process in a mammal where this process has been diminished due to pathology or a condition that require osteogenesis. Osteocalcin is an endogenous inhibitor of the PHEX activity. Therefore, the identification of a substance capable of potentiating PHEX activity by preventing the inhibitory action of endogenous inhibitors will improve osteogenesis. Since PHEX is generally associated with the growth plane of bone or teeth and the absence of osteocalcin is associated with increased bone mass, potentiation of PHEX activity can promote bone growth. Increased PHEX activity can also be obtained by administration of the enzyme itself.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.