Methods for cardiac gene transfer

US7399750B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Kenneth R. Chien · Cambridge, US
• Masahiko Hoshijma · San Diego, US
• John F. Ross · Village of La Jolla, US
• Yasuhiro Ikeda · Rochester, US

Key dates

• Filing date: Sep 11, 2001
• Grant date: Jul 15, 2008
• Expiry date: Sep 11, 2021

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2750/14143
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for the delivery of genes to improve cardiac function including the use of viral vectors, isolation of the heart from systemic circulation, and induction of hypothermia/cardiac arrest are described. The method results in high-level, long-term expression of reporter genes and enhanced cardiac function in hamster models of heart disease.