Trans-splicing mediated photodynamic therapy
US7399753B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 9, 2003 |
| Grant date | Jul 15, 2008 |
| Priority date | — |
| Expiry date | Nov 24, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2840/445
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention provides methods and compositions for conferring selective death on cells expressing a specific target precursor messenger RNA (selective target pre-mRNA). The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) expressed within a cell and mediate a trans-splicing reaction resulting in the generation of a novel chimeric mRNA molecule (chimeric mRNA) capable of encoding a light producing protein or enzyme. Cell death is further mediated by the presence of a photosensitizer which upon photoactivation produces cytotoxicity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.