Heterocyclic benzo[c]chromene derivatives useful as modulators of the estrogen receptors
US7399767B2 · kind B2 · utility
26Cited by
2References
9Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 18, 2006 |
| Grant date | Jul 15, 2008 |
| Priority date | — |
| Expiry date | Jan 18, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to novel heterocyclic benzo[c]chromene derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders mediated by one or more estrogen receptors. The compounds of the invention are useful in the treatment of disorders associated with the depletion of estrogen such as hot flashes, vaginal dryness, osteopenia and osteoporosis; hormone sensitive cancers and hyperplasia of the breast, endometrium, cervix and prostate; endometriosis, uterine fibroids, osteoarthritis and as contraceptive agents, alone or in combination with a progestogen or progestogen antagonist.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.