N-oxides and derivatives of melphalan for treating diseased states associated with hypoxia inducible factor
US7399785B2 · kind B2 · utility
11Cited by
1References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 30, 2004 |
| Grant date | Jul 15, 2008 |
| Priority date | — |
| Expiry date | Jun 1, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F9/65846
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases. These compounds have the general formula set out below and are used to treat a variety of diseases associated with HIF:wherein R is an alkyl, aryl, arakyl or derivatives thereof such as CH3OCH2CH2—, CH3CH2OCH2CH2—, C6H5OCH2CH2—, C6H5CH2—, CH3(CH2)3OCH2CH2Cl; or any one of the following:
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.