Compounds, compositions, and methods

US7399866B2 · kind B2 · utility

Assignee

• CYTOKINETICS, INC. · US

Inventors

• Bradley P. Morgan · Moraga, US
• Kathleen Ann Elias · San Francisco, US
• Erica Anne Kraynack · South San Francisco, US
• Pu-Ping Lu · Foster City, US
• Fady Malik · Burlingame, US
• Alex Muci · South San Francisco, US
• Xiangping Qian · Foster City, US
• Whitney W. Smith · South San Francisco, US
• Todd Tochimoto · Foster City, US
• Adam Lewis Tomasi · San Francisco, US
• David J. Morgans, Jr. · Los Altos, US

Key dates

• Filing date: Jan 14, 2004
• Grant date: Jul 15, 2008
• Expiry date: Jan 14, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, are useful in the treatment of systolic heart failure including congestive heart failure.