Histone deacetylase inhibitors

US7399884B2 · kind B2 · utility

Assignee

• Takeda San Diego, Inc. · US

Inventors

• Jerome C. Bressi · San Diego, US
• Sheldon Cao · San Diego, US
• Jeffrey Alan Stafford · San Diego, US
• Phong Vu · San Diego, US

Key dates

• Filing date: Nov 7, 2006
• Grant date: Jul 15, 2008
• Expiry date: Nov 7, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D241/44
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Histone deacetylase inhibitors and uses thereof are provided that have the general formulawhereinR1, R2, R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted straight chained C1-12 alkyl, C2-12 aminoalkyl or C2-12 oxaalkyl, and a substituted and unsubstituted 3, 4, 5, 6, 7 or 8 membered ring, with the proviso that R3 and R4 are not both hydrogen;R5 is selected from the group consisting of a carbonyl, a substituted or unsubstituted C1-3 alkyl, a substituted or unsubstituted —C1-3 alkyl-C(O), a substituted or unsubstituted —C(O)—C1-3 alkyl, and a substituted or unsubstituted —C(O)C(O)C1-3 alkyl;M is a substituent capable of complexing with a protein metal ion; andL is a substituent comprising a chain of 3-12 atoms connecting the M substituent to the carbon atom alpha to the L substituent.