Receptor tyrosine kinase signaling pathway analysis for diagnosis and therapy
US7402399B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Oct 13, 2004 |
| Grant date | Jul 22, 2008 |
| Priority date | — |
| Expiry date | Sep 5, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2333/485
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention provides a method for determining the activation status of receptor tyrosine kinase (RTK) pathways in either cell samples or patient samples by measuring receptor dimerization and relative amounts of protein-protein complexes or activated effector proteins that are characteristic of an RTK pathway. The invention also provides a method of using such status information to select patients responsive to pathway-specific drugs, and more particularly, to methods for measuring ErbB receptors and receptor complexes and using such information to select patients responsive to ErbB pathway-specific drugs. Preferably, methods of the invention are implemented by using sets of binding compounds having releasable molecular tags that are specific for multiple components of one or more complexes formed in RTK activation. After binding, molecular tags are released and separated from the assay mixture for analysis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.