P450 oxygenases and methods of use
US7402417B2 · kind B2 · utility
2Cited by
3References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 21, 2004 |
| Grant date | Jul 22, 2008 |
| Priority date | — |
| Expiry date | Dec 12, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/0069
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
This disclosure provides the nucleic acid and protein sequences of novel P450 oxygenases that utilize, at least, taxoid substrates, including taxadiene isomers. The disclosed oxygenases, such as a taxoid 5α-hydroxylase, hydroxylate, at least, the C5 position of a taxoid. Also provided are methods of introducing oxygen at the C5 position of a taxoid and methods of producing the anti-cancer drug, paclitaxel (also known as Taxol™), and other taxoids, such as paclitaxel intermediates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.