Crystalline forms of a pyridinyl-sulfonamide and their use as endothelin receptor antagonists

US7402587B2 · kind B2 · utility

Assignee

• Speedel Pharma AG · CH

Inventors

• Thierry Briand · Chatou, FR
• Alexander Bilz · Bad Krozingen, DE
• Fritz Blatter · Reinach, CH
• Martin Szelagiewicz · Münchenstein, CH

Key dates

• Filing date: May 12, 2005
• Grant date: Jul 22, 2008
• Expiry date: May 12, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Crystalline forms A and B of 5-methyl-pyridine-2-sulfonic acid [6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide of formula (I) are described, whereby form B is the most stable form. 5-methyl-pyridine-2-sulfonic acid [6-methoxy-5-(2-methoxy-phenoxy)-2-pyridin-4-yl-pyrimidin-4-yl]-amide also forms solvates with, for example, ethanol, acetone, tetrahydrofuran, methanol, isopropanol, 2-butanone and dichloromethane.