Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis

US7404952B2 · kind B2 · utility

Assignee

• DeveloGen Aktiengesellschaft fuer Entwicklungsbiologische Forschung · DE

Inventors

• Karsten Eulenberg · Bovenden, DE
• Gunter Bronner · Göttingen, DE
• Thomas Ciossek · Oebisfelde, DE
• Thomas Hader · Göttingen, DE
• Arnd Steuernagel · Göttingen, DE

Key dates

• Filing date: Dec 5, 2006
• Grant date: Jul 29, 2008
• Expiry date: Dec 17, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, antibodies, and recombinant methods for producing the polypeptides and polynucleotides of the invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as adipositas, eating disorders, wasting syndromes (cachexia), pancreatic dysfunctions (such as diabetes mellitus), hypertension, pancreatic dysfunctions, arteriosclerosis, coronary artery disease (CAD), coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, cancer, e.g. cancers of the reproductive organs, sleep apnea, and others.