Glycopegylated erythropoietin
US7405198B2 · kind B2 · utility
38Cited by
38References
36Claims
0Family size
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Key dates
| Filing date | Nov 24, 2004 |
| Grant date | Jul 29, 2008 |
| Priority date | — |
| Expiry date | Nov 24, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides conjugates between erythropoietin and PEG moieties. The conjugates are linked via an intact glycosyl linking group interposed between and covalently attached to the peptide and the modifying group. The conjugates are formed from glycosylated peptides by the action of a glycosyltransferase. The glycosyltransferase ligates a modified sugar moiety onto a glycosyl residue on the peptide. Also provided are methods for preparing the conjugates, methods for treating various disease conditions with the conjugates, and pharmaceutical formulations including the conjugates.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.