Transcription factor modulating compounds and methods of use thereof

US7405235B2 · kind B2 · utility

Assignee

• Paratek Pharmaceuticals, Inc. · US

Inventors

• Stuart B. Levy · Boston, US
• Michael N. Alekshun · Wakefield, US
• Brent L. Podlogar · Hamden, US
• Kwasi Ohemeng · Clinton, US
• Atul K. Verma · Mansfield, US
• Tadeusz Warchol · Northborough, US
• Beena Bhatia · Mansfield, US
• Todd Bowser · Charlton, US
• Mark Grier · San Diego, US

Key dates

• Filing date: Nov 3, 2003
• Grant date: Jul 29, 2008
• Expiry date: Jan 16, 2025

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02A50/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms.