Chemical methods
US7405301B2 · kind B2 · utility
13Cited by
4References
22Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 2001 |
| Grant date | Jul 29, 2008 |
| Priority date | — |
| Expiry date | Feb 6, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D489/02
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates to a method for N-demethylating an N-methyl morphinane comprising the steps of: (i) treating said N-methyl morphinane with an oxidizing agent to form the N-oxide morphinane; and (ii) treating said N-oxide morphinane with a reducing agent. This invention also relates to a method for oxidizing a Δ7-morphinane compound to a Δ6, Δ8-morphinane compound, comprising the steps of treating said Δ7-morphinane with γ-MnO2 for a time and under conditions sufficient to oxidize said Δ7-morphinane, and treating the γ-MnO2 with glycol or a derivative thereof, and/or an inorganic salt.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.