System and method for consensus-calling with per-base quality values for sample assemblies
US7406385B2 · kind B2 · utility
102Cited by
1References
18Claims
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Key dates
| Filing date | Oct 23, 2002 |
| Grant date | Jul 29, 2008 |
| Priority date | — |
| Expiry date | Mar 8, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B30/00
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
The present teachings disclose a method for evaluation of a polynucleotide sequence using a consensus-based analysis approach. The sequence analysis method utilizes quality values for a plurality of aligned sequence fragments to identify consensus basecalls and calculate associated consensus quality values. The disclosed method is applicable to resolution of single nucleotide polymorphisms, mixed-based sequences, heterozygous allelic variants, and heterogeneous polynucleotide samples.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.