Methods, kits and pharmaceutical compositions for diagnosing, delaying onset of, preventing and/or treating osteoporosis

US7407753B2 · kind B2 · utility

Assignees

• YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. · IL
• Institut National de la Sante et de la Recherche Medicale (INSERM) · FR
• Andreas Zimmer · DE
• Meliha Karsak · DE

Inventors

• Andreas Zimmer · Graz, AT
• Meliha Karsak · Bonn, DE
• Marie-Christine De Vernejoul · Paris, FR
• Itai Bab · Mazkeret Batya, IL
• Esther Shohami · Mevaseret Tsiyon, IL
• Raphael Mechoulam · Jerusalem, IL

Key dates

• Filing date: May 24, 2004
• Grant date: Aug 5, 2008
• Expiry date: Nov 11, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/172
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The present invention uncovers a highly significant association of SNPs in the CNR2 locus, encoding the cannabinoid receptor 2 protein, with osteoporosis. Methods and kits for determining predisposition to osteoporosis, improving diagnosis in individuals suspected of having osteoporosis are provided. Also provided a method of identifying a putative osteoporosis-causing genetic mutation in a subject.